Gynecomastia , that is, breast enlargement, has become a hallmark of the power and curse of Sports. Larger men grow breasts, but it is not in transsexuality.Everything is much easier – to blame steroids. Evil demon inflicting effeminate men, is a female sex hormone – estrogen. Actually estrogen is a group of female sex hormones are synthesized in the body and the ovaries regulate specific sexual functions. Rather it would speak of estrogens because they have two (in both women and men). The main and most powerful of them – 17-beta estradiol, which is mainly obtained in the ovaries of progesterone. Smaller amounts can be obtained from testosterone by enzymatic reactions. In the male body the whole estradiol produces an enzyme, called aromatase. Even the one that stands out in the testicles (. Simply, eggs Here is the scientific name, not to be confused with women’s ovaries – author’s note.), Derived from testosterone released by the Leydig cells by enzymatic conversion in the Sertoli cells. Second, a weak estrogen – estrone. It is also synthesized by the ovaries of allocated adrenal androstenedione. Estrogens are naturally present in the male body, as have a number of important functions. Many areas of the brain contain estrogen receptors. In 1981 godu it hypothesized that estrogens regulate the level of luteinizing hormone and hence testosterone in men and animals of male gender. Around the same time it was suggested the possibility of (safe, although too radical) increase testosterone levels by inhibiting synthesis of estrogen; German scientists have published similar speculation. In addition, estrogens are involved in the regulation of libido, sexual desire ie, maintain an acceptable level of high density lipoprotein ( “good”) cholesterol and regulate fetal development of the placenta. In addition to all the above, testosterone and estrogen work synergistically – without their mutual muscles will not grow.Therefore, maintaining the balance in the male body is as follows: we are going to reduce the level of estrogen just enough to prevent gynecomastia, and the rest of them are still regulates libido and level of “good” cholesterol. Those who take anabolic steroids, there are two possibilities. Either they will avoid steroids, convert to estrogen or anti-estrogen agent How to build hand – professional advice 10 used. Even “clean” athlete would like to raise the level of testosterone. And antiestrogens provide such an opportunity. Because these drugs are widely used (as fixed assets) in the treatment of estrogen-dependent breast cancer, we have a choice. There are four broad categories of antiestrogens: non-steroidal antagonists, steroid antiaromataznye means antiaromataznye synthetic remedies and natural aromatase blockers. Let’s talk about some of them.
Non-steroidal estrogen antagonists
These drugs were discovered in 1980 and originally used as a means to prevent estrogen-dependent cancer in women (see, for example, a review of:. Pharmaceutical Chemistry Journal, 1990, No. 5, pp 4-7.). Later, bodybuilders and other athletes who abuse steroids, have begun to use them to fight gynecomastia caused by large doses of anabolic drugs.
Novaldeks (tamoxifen citrate) is the most famous in the world of bodybuilding. This is one of two commercially available nonsteroidal antagonists (second – Clomid). Hormone antagonist structurally correspond to a receptor for the hormone, so that the latter can not exert its effect. Theoretically, the antagonist must not in any way affect the receptor, without causing any effects. In fact, the hormones antagonists cause problems. Novaldeks – a classic example of an antagonist, giving very different results. The man Novaldeks on one cell acts as an antagonist on the other – both estrogen.V a new generation of derivatives of tamoxifen, virtually non-estrogenic effect over the coming years. But now Novaldeks effectively blocks estrogen in some women with breast cancer. Some women are resistant to the drug, and their blood levels of estrogen may even rise According to some scientific data, men Novaldeks reduces the size of the swollen breast, but only if it did not come to the formation of benign tumors. Otherwise, the best (and usually only) operation is salvation. No studies proving Novaldeksa effect on the estrogen receptors in the brain controls various hormones that regulate the synthesis of testosterone. In other words, Novaldeks not affect the synthesis of the hormone. It is interesting that according to the comments of some male bodybuilders Novaldeks slows muscle growth (although women observed the opposite effect). Rather strange phenomenon! Possible side effects include gastrointestinal upset, dizziness, skin rash. As an anticancer agent taking one tablet (10 mg) twice a day. Now we continue the study on the use of tamoxifen, a long-used cancer drug, Novaldeks has estrogenic effects in the uterus and therefore can trigger cervical cancer.Female bodybuilders still use it as a means to redistribute fat. He’s a bit active, but in this role for a long time does not justify the cost. Novaldeks antiestrogen remains a favorite for bodybuilders. As the “curing” means before the event it is used by both men and women. Men taking steroids via Novaldeksa prevent gynecomastia and reduce the size of the tumor (benign) breast. Since antiestrogens seem to be specific to breast tissue, their use for this purpose seems the best solution. Although many people take these drugs, noted an increase in testosterone levels in the blood, and the cases are marked increase estrogen levels.
Clomid (clomiphene) was originally to work as an estrogen antagonist. In fact he has a dual action (agonist / antagonist) and ie blocks the effects of estrogen receptors and mimics the action of luteinizing hormone, estrogen increases synthesis in the ovaries. When it was found that long-term use of Clomid causes cysts (bubble growths in the ovaries, it began to prescribe short courses (up to 5 days) to improve fertility, however, for Clomid men has a very useful dual action:. It blocks the effects of estrogen and increases testosterone levels. It looks like Clomid is safe for men with a long reception, but no reports of its effects on libido Clomid blocks the effects of estrogen and also increases the level of testosterone men usually use two tablets per day (see: Dan Duchaine estrogen blockers – MuscleMedia 2000, February…. 1997, p. 138)
Steroid antiaromataznye means
Proviron (Mesterolone) – a steroid having antiaromataznoy activity. Such formulations are usually androgen and testosterone competes with androstenedione at the level of the enzyme cytochrome 450, changing its estrogenic activity and preventing action. The most famous among them Proviron. Its shortcomings are obvious: as the androgen, he joins the androgen receptor, and shows the corresponding side effects. For men, it does not seem a particularly serious problem;however Proviron has a strong affinity for testosterone receptors and displaces most out of anabolic steroids without giving any anabolic effect. Therefore, it can compete with steroids in muscle cells and to slow or even stop the growth of muscle. Proviron is used by both men and women to “cure” before competition, and the men take it as a remedy for gynecomastia. This is not the best anti-estrogen for women, since it is a potent androgen like testosterone. However, for short-term use of steroid Proviron bad consumers, even though it may displace steroids receptors in muscle cells. His most often used in conjunction with Anadrol-50.5-alpha-androstenedione. Very strange and promising antiaromataznoe means; It seems more promising than the “Flavon X” (chrysin). Production of estrogen in the placenta is regulated natural adrenal hormones – dehydroepiandrosterone metabolites. Estrone is synthesized from androstenedione, and the androgen secreted by the adrenal glands – the main source of estrogen in postmenopausal women. The same enzyme 5-alfareduktaza converts testosterone to “sverhandrogenny” DHT from androstenedione and generates a 5-alpha-androstenedione (5AA). However, human studies on the impact of this drug, no, and we have no idea what should be the therapeutic dose for moderate suppression of aromatase activity. Moreover, subsequent enzymatic reactions can convert 5-alfareduktazu inactive ingredient.This drug directly asks in the studies conducted on men! Another cool feature: 5-alfareduktaza goes well with undecylenate boldenone (Equipoise). So if this drug will ever be commercially available, you will see a large number of illegally produced Equipoise. Although 5-alfareduktaza might have the same qualities as the other steps in this article a substance, it has not yet been tested on humans, and it remains a great mystery.
Teslac. This medication can be called steroid antiaromataznym means, as it turns out bacterial fermenting progesterone and structurally similar to androgens.However, it does not have any androgenic effects, although increases testosterone levels in men. Unlike aminoglutethimide, also synthetic antiaromataznogo preparation Teslac not affect other enzyme systems. Since Teslac acts very short period of time, usually the day you need 4 doses of 250 mg. It is commonly used in studies on the effect of estrogen on the libido and the level of “good” cholesterol as the primary means of antiaromataznoe. Teslac – a very effective medication with reduced side effects (although sometimes it lowers libido or violates cholesterol profile). On paper Teslac antiestrogen seems ideal, as it prevents the synthesis of estrogen, and does not interfere with their action after selection. He’s not too good dlyazhenschin as a young female body is a big part of the estrogen, progesterone from the ovaries, and Teslac is not affected.
Cytadren (aminoglutethimide) – “King” antiaromatase. If the dose reaches 2.1 grams, it has an adverse effect on the activity of other enzyme systems. A decrease in the levels of aldosterone, cortisol, and even testosterone. But if a woman of childbearing age is resistant to tamoxifen, Cytadren can literally save her life because the dose of about two grams per day fully stop the allocation of dehydroepiandrosterone, so it stops the synthesis of hormones derived from it (all estrogens, progesterone). Remember: trying to remove estrogens, you should know exactly what you want to achieve! Without estrogen (as a result of receiving powerful antiaromataznyh drugs) you are sure to become impotent, the risk of getting heart disease (because of the low level of “good” cholesterol), gaga (estrogen in the brain to improve intelligence) and, among other things, acquire a predisposition to osteoporosis. A recent study examined the brothers and sisters who were born without estrogen. Men achieved growth of more than 210 cm (estrogens cause the closure of the growing ends of the long bones, stopping their growth), but the bones are soft and porous. Cytadren reception in a very low dose (250 mg per day, i.e., one tablet) causes a sharp drop in men aromatase activity and a corresponding increase in testosterone levels without significant side effects. As a means of kushigi syndrome, used in high doses (2 grams per day), Cytadren is not suitable for sports. But very small doses (250 mg daily) cause an increase in natural testosterone levels almost without any side effects. However, against gynecomastia Novaldeks better, since it is specific to the breast tissue.
Arimidex (anastrozole), it seems the most powerful among antiaromataznyh synthetic drugs. Actually men it may be too powerful! For post-menopausal women with low estrogen levels and ill breast cancer, it is almost perfect: one milligram per day in just a few days removes all traces of estrogen. Period poluvyvoda preparation – from 30 to 60 hours (!). Due to the high activity Arimidex can arrange a mess in the male body, even at doses of 1 mg / day. Perhaps it turns out that the effective dose to increase the level of testosterone – a quarter of a tablet every two days. In terms of doses Arimidex – the most profitable and Effectiveness of all antiestrogens. This drug is the most recent and promising. Over time, we will find doses that result in higher levels of testosterone in men without decreasing libido.He’s not very good for women as it does not act on the ovaries, and they continue to emit large amounts of their own estrogen. But to increase testosterone levels in men Arimidex just fine. However, it is not known whether it may prevent or reduce gynecomastia as Novaldeks.
Alfa naphthoflavone Flavones – natural compounds that have the properties of antioxidants, antibiotics and antiviral agents. Alfa naphthoflavone has the most powerful effect antiaromataznym: it is 10 times stronger than aminoglutethimide. Some other synthetic flavones, biochanin A, and for example 4-methyl ether of genistein not only weak inhibitors of aromatase, but also possess oestrogenic activity
Flavon X (chrysin, 7 hydroxyflavone) – is not the most powerful of flavones. The approximate daily dose of the compound – about one and a half grams. Although chrysin to 6 times weaker than the synthetic alpha-naphthoflavone, he nevertheless strongly inhibits aromatase than Cytadren. However, chrysin is not perfect: it disrupts the work of other enzyme systems, including 5-deyodazy which converts T4 – L-thyroxine (thyroid hormone) into a more active T3 – triiodo-L-thyronine. It would be interesting to compare chrysin with other so-called “legitimate” means antiaromataznymi – 5-alpha-androstenedione. Eventually, one of these additives on the market probetsya. It looks like chrysin has all the attributes antiaromataznyh funds – that is, raises testosterone levels and prevents gynecomastia, but can not be sold on prescription. In addition, he visibly useless for female bodybuilders. Praise lavished Dyusheynom this drug seem to be greatly exaggerated, especially against the background of the following critical comments (blame Shortcuts on the publication could not be found to us).
Possible health problems arising from the “two-legged guinea pigs” who are trying to raise natural testosterone levels with help of various antiaromatase, due to the fact that hardly any of them will do blood tests required to monitor cholesterol levels. Remember that some amount of estrogen needed for the male metabolism.We need a method of trial and error to find an acceptable balance between the capacity for work in the room, in bed, and health. That’s why we strongly recommend you to work with a doctor who would monitor your blood condition in experiments with one of these compounds. Of course, there are exceptions – men who do not care about the excess estrogen. Well, go to the navel with sagging breasts! Small dictionary “curing agents”: a drug that reduces the level of estrogen, so that the level of thyroid hormones (thyroid hormone) increases and fat from the skin begins to diverge. As a result, the skin becomes thinner, and can be seen through it all, even the smallest muscle. This process nazyyvaetsya curing.
Gynecomastia: breast enlargement in men above normal due to the high content of estrogen in the blood. First there is a swelling and then formed benign tumor.At the initial stage helps estrogens. However, the tumor can only be removed by surgery. Increased levels of testosterone: male body begins to produce less testosterone, when he feels that it is converted into estrogen (as with steroids). If lower levels of estrogen, the brain gives the body the command to produce more stimulating hormones. This phenomenon is well known for decades, but only recently builders have started to use it in practice.